Title: Intervention strategies for cesarean section–induced alterations in the microbiota-gut-brain axis
| Authors: | Moya-Pérez A, Luczynski P, Renes IB, Wang S, Borre Y, Anthony Ryan C, Knol J, Stanton C, Dinan TG, Cryan JF |
| Published: | 2017 |
| Journal: | Nutrition Reviews |
The vertical transmission of maternal microbes to the offspring is a critical factor for host immune and metabolic development. Increasing evidence also points to a role in the wiring of the gut-brain axis. This process may be altered by various factors such as mode of delivery, gestational age at birth, the use of antibiotics in early life, infant feeding, and hygiene practices.
This review summarises how C-sections can alter microbiota colonisation in gut, influencing the functioning of the immune and neuroendocrine systems, with long-lasting effects on health.
The review also discusses possible preventative and restorative strategies (including the use of pre-and pro-biotics) to compensate for early-life microbial perturbations, reversing the undesirable effects induced by C-sections.