Physical Frailty

Innovating nutritional solutions to target mobility and independence

The loss of skeletal muscle mass, strength and function during the ageing process can have an enormous impact on an individual’s life and quality of it. It can lead to mobility disorders, increased risk of falls and fractures, impaired ability to perform activities of daily living, physical disabilities, loss of independence and increased mortality. Maintaining our muscle mass, strength and function as we age, and/or recovering our muscle during or after diseases and rehabilitation is therefore key. Danone Nutricia Research, alongside academic partners, has been working within the field of muscle and sarcopenia for over a decade. We have been examining the changes in muscle metabolism that occur with ageing, with the aim of developing viable nutritional strategies to improve and preserve muscle mass, strength and function in sarcopenic and physically frail older people.


This understanding led to the development of a medical nutrition product range, which contain a unique blend of muscle building nutrients, i.e. whey protein, leucine and vitamin D, designed to help stimulate muscle protein synthesis and support muscle mass, strength and function. The combination of nutrients in the product have been shown to stimulate muscle protein synthesis1,2,3,4 and muscle mass gain5,6 in healthy and sarcopenic older adults.

Chanet A, et al. Supplementing breakfast with a vitamin D and leucine-enriched whey protein medical nutrition drink enhances postprandial muscle protein synthesis and muscle mass in healthy older men. J Nutr. 2017;147(12):2262-71.
Luiking YC, et al. Postprandial muscle protein synthesis is higher after a high whey protein, leucine-enriched supplement than after a dairy-like product in healthy older people; a randomized controlled trial. Nutr J. 2014;13:9.
Kramer IF, et al. Clin Nutr. 2016 Sep 29. pii: S0261-5614(16)31263-8
Kramer IF, et al. J Clin Endocrinol Metab. 2015 Nov;100(11):4124-32.
Bauer JM, Verlaan S, Bautmans I, Brandt K, Donini LM, Maggio M, McMurdo ME, Mets T, Seal C, Wijers SL, Ceda GP, De Vito G, Donders G, Drey M, Greig C, Holmback U, Narici M, McPhee J, Poggiogalle E, Power D, Scafoglieri A, Schultz R, Sieber CC, Cederholm T. Effects of a Vitamin D and Leucine-Enriched Whey Protein Nutritional Supplement on Measures of Sarcopenia in Older Adults, the PROVIDE Study: A Randomized, Double-Blind, Placebo-Controlled Trial. J Am Med Dir Assoc 2015;16(9):740-7.
Chanet A, Verlaan S, Salles J, Giraudet C, Patrac V, Pidou V, Pouyet C, Hafnaoui N, Blot A, Cano N, Farigon N, Bongers A, Jourdan M, Luiking Y, Walrand S, Boirie Y. Supplementing Breakfast with a Vitamin D and Leucine-Enriched Whey Protein Medical Nutrition Drink Enhances Postprandial Muscle Protein Synthesis and Muscle Mass in Healthy Older Men. J Nutr. 2017;147(12):2262-71.