Title: 24-month intervention with a specific multinutrient in people with prodromal Alzheimer’s disease (LipiDiDiet): a randomised, double-blind, controlled trial
|Authors:||Hilkka Soininen, Alina Solomon, Pieter Jelle Visser, Suzanne B. Hendrix, Kaj Blennow, Miia Kivipelto, Tobias Hartmann, on behalf of the LipiDiDiet clinical study group|
The Lancet Neurology
The LipiDiDiet clinical trial investigated the effects of a medical nutrition drink on cognition and related measures in a very early stage of Alzheimer’s disease. The results of this two year intervention did not show significant effects on overall cognition – the primary endpoint – however the intervention did show a significant benefit on everyday cognitive and functional performance, as well as a significant reduction of hippocampal atrophy, which are both measures of disease progression.