Title: Synbiotics-supplemented amino acid-based formula supports adequate growth in cow’s milk allergic infants.
|Authors:||Burks AW, Harthoorn LF, Van Ampting MTJ, Oude Nijhuis MM, Langford JE, Wopereis H, Goldberg SB, Ong PY, Essink BJ, Scott RB, Harvey BM|
Pediatric Allergy and Immunology
This prospective, randomised, double-blind controlled study assessed growth of cows’ milk allergic (CMA) infants when using a new amino acid-based formula (AAF) with prebiotics and probiotics (synbiotics) and evaluated its safety. Full-term infants with diagnosed CMA received either an AAF or AAF with synbiotics (oligofructose, long-chain inulin, acidic oligosaccharides, Bifidobacterium breve M-16V) for 16 weeks. Results showed that both formulas equally supported growth and resulted in similar increases of weight, length and head circumference. Both formulas were well tolerated and reduced allergic symptoms. This is the first study that shows that an AAF with a specific synbiotic blend, suitable for CMA infants, supports normal growth and growth similar to the AAF without synbiotics.