Growth & Metabolism / Preterm

A history of expertise in prebiotic science in preterms

The intestinal microbiota play a key role in postnatal development of the immune system.1,2 Supporting the development of a healthy microbiota and reducing the pathogen load early in life is important to secure a stable and healthy microbiota later in life.

Premature infants are at risk of developing an imbalance in their microbiota composition, which can have a negative effect on their immune system, increasing their risk of infections.

Oligosaccharides are found in abundance within human milk; they are bioactive components that exert a prebiotic effect. In 1998, Danone Nutricia Research launched a unique and patented blend of prebiotics (short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides – scGOS:lcFOS [9:1]) that were designed to mimic the natural prebiotic effect of the oligosaccharides found in human milk.

Clinical trials in preterm infants have shown that the supplementation of scGOS:lcFOS  (9:1) to a preterm formula promotes a microbiota composition more similar to that of breastfed infants by:

  • increasing the concentration and proportion of bifidobacteria3
  • discouraging the growth of potential pathogens3

Almost 20 years of research, covered in over 40 studies described in  75  publications, validate the health benefits of scGOS/lcFOS (9:1)
  • Promoting colonisation with healthy gut bacteria similar to human milk fed infants and reducing presence of potentially harmful bacteria4,5
  • Lower incidence of infections6
  • Increased stool frequency and softer stools7,8
  • Reduced incidence of allergic symptoms, such as atopic dermatitis in term infants9,10

View References

Cebra JJ. Am J Clin Nutr, 1999;69:1046s-1051s.
Kemp A, et al. Pediatr Allergy Immunol, 2003;4:74-80.
Boehm G, et al. Arch Dis Child Fetal Neonatal, 2002; 86: f178-81.
Knol J, et al. Acta Paediatr. Suppl 2005;94:31-3.
Harmsen HJ, et al. J Pediatr Gastroenterol Nutr, 2000;30:61-7.
Bruzzese E, et al. Clin Nutr, 2009;28:156-61.
Dasopoulou M, et al. J Parent Enteral Nutr, 2013:doi 10.1177/0148607113510182.
Mihatsch WA, et al. Acta Paediatr, 2006; 95:843-8.
Arslanoglu S, et al. J Nutr, 2008;138:1091-5.
Moro G, et al. Arch Dis Child, 2006;91(10):814-9.