Title: Complex lipid globules in early-life nutrition improve long-term metabolic phenotype in intra-uterine growth-restricted rats
|Authors:||Teller, Inga C. Hoyer-Kuhn, Heike Brönneke, Hella Nosthoff-Horstmann, Pia Oosting, Annemarie Lippach, Gregor Wohlfarth, Maria Rauh, Manfred van der Beek, Eline M. Dötsch, Jörg Nüsken, Kai D.|
|Published:||August 14, 2018|
British Journal of Nutrition, 1-14. doi: 10.1017/S0007114518001988
Term infants born small-for-gestational age (SGA; >37 weeks gestation and <10th percentile) are at risk for fast catch-up growth increasing the risk of noncommunicable diseases later in life. Breast-feeding and breast-feeding duration have been associated with a moderate, yet consistent, reduction of childhood obesity risk and later metabolic disease. In breast-fed SGA infants, enhanced early growth and lower circulating adverse metabolic markers hint at the possible protective effects of breast feeding in metabolic health.
Lipids in Human milk
One distinct characteristic in human milk is that lipids are present as large globules surrounded by a complex triple-layered phospholipid membrane. Due to processing, lipids in infant formulae are present as droplets that are generally 10 times smaller and with proteins adhering to the interphase.
Danone Nutricia Research developed an infant formula concept with large, phospholid coated lipid droplets (mode diameter 3-5 μm; NUTURIS®)1. The current publication describes the protective effects of this concept on metabolic health in rodents born growth restricted that experience catch-up growth. The animals were exposed to Nuturis® or control diet, starting during the weaning period. Subsequently animals were challenged with a moderate Western Style diet during adolescence and young adulthood.
The Nuturis® concept protected against adiposity development as well as improved specific metabolic outcomes in the model compared to controls.
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