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Partly Fermented Infant Formulae With Specific Oligosaccharides Support Adequate Infant Growth and Are Well-Tolerated.

Title: Partly Fermented Infant Formulae With Specific Oligosaccharides Support Adequate Infant Growth and Are Well-Tolerated.

Authors: Huet F, Abrahamse-Berkeveld M, Tims S, Simeoni U, Beley G, Savagner C, Vandenplas Y, Hourihane JO
Published: 2016
Journal:

Journal of Pediatric Gastroenterology and Nutrition

Historically, fermented formulae are used to promote digestibility and tolerance and are considered safe for use in infants (with respect to growth). Infant formulae containing the specific prebiotic mixture of 90% short-chain galacto-oligosaccharides and 10% long-chain fructo-oligosaccharides (scGOS/ lcFOS; 9:1) closer mimics human milk gut microbiota and stool characteristics, have a beneficial effect on immune function and are considered safe for use in infants.

Fermented formulae and a specific mixture of 90% short chain galacto-oligosaccharides and 10% long-chain fructo-oligosaccharides (scGOS/lcFOS; 9:1) have a potential beneficial effect on gastrointestinal function and microbiota development in infants. The present study assessed the safety and tolerance of the combination of partly fermented infant milk formulae and scGOS/lcFOS in healthy term infants.

The partly fermented infant milk formulae containing the specific mixture scGOS/lcFOS were well-tolerated and resulted in normal growth in healthy infants. Irrespective of presence or dosage of fermented formula, beneficial effect of scGOS/lcFOS (9:1) on gut microbiota and stool characteristics was confirmed, indicated by the lower pH, lower Clostridium difficile levels, and higher secretory immunoglobulin A levels.

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Citation: Huet F, Abrahamse-Berkeveld M, Tims S, Simeoni U, Beley G, Savagner C, Vandenplas Y, Hourihane JO. Partly Fermented Infant Formulae With Specific Oligosaccharides Support Adequate Infant Growth and Are Well-Tolerated. J Pediatr Gastroenterol Nutr. 2016;63(4):e43-53