At Nutricia Research, we are committed to develop high quality nutritional products with scientifically-proven benefits for each phase of early life, aiming to give children worldwide a healthy start in life.

Prebiotic oligosaccharides are an abundant bioactive component in human milk. We have developed a patented mixture of prebiotics, similar to human milk, short-chain galacto-oligosaccharides scGOS/lcFOS (9:1). The health benefits of scGOS/lcFOS (9:1) are validated by almost 20 years of research, with a total of over 30 studies, described in >55 scientific publications.
These health benefits include:

  • Reduced incidence of allergic symptoms, such as atopic dermatitis [ 1, Arslanoglu, S., et al., Early dietary intervention with a mixture of prebiotic oligosaccharides reduces the incidence of allergic manifestations and infections during the first two years of life. J Nutr, 2008. 138(6): p. 1091-5. 2, Arslanoglu, S., et al., Early neutral prebiotic oligosaccharide supplementation reduces the incidence of some allergic manifestations in the first 5 years of life. J Biol Regul Homeost Agents, 2012. 26(3 Suppl): p. 49-59. 3, Moro, G., et al., A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age. Arch Dis Child, 2006. 91(10): p. 814-9. 4 Gruber, C., et al., Reduced occurrence of early atopic dermatitis because of immunoactive prebiotics among low-atopy-risk infants. J Allergy Clin Immunol, 2010. 126(4): p. 791-7. ]
  • Increased level of healthy gut bacteria and reduced level of potentially harmful bacteria [ 5 Haarman, M. and J. Knol, Quantitative real-time PCR assays to identify and quantify fecal Bifidobacterium species in infants receiving a prebiotic infant formula. Appl Environ Microbiol, 2005. 71(5): p. 2318-24. ]
  • Reduced occurrence of infections¬†[ 6, Martin, R., et al., Early life: gut microbiota and immune development in infancy. Benef Microbes, 2010. 1(4): p. 367-82. 7 Jeurink, P.V., et al., Human milk: a source of more life than we imagine. Benef Microbes, 2013. 4(1): p. 17-30. ]
  • Improved stool frequency and consistency

We also demonstrated that the favourable health benefit of the use of this specific mixture of prebiotics scGOS/lcFOS (9:1) results in positive short and long-term health economic benefits (Lenoir-Wijnkoop et al. 2013).

SYNBIOTICS scGOS/lcFOS (9:1) and Bifidobacterium breve M-16V
Bifidobacterium breve is commonly found in human milk and in the gut of breastfed infants. Our research demonstrated that Bifidobacterium breve M-16V is the most promising strain in reducing allergic symptoms and in producing synergistic benefits when combined with our unique prebiotic mixture scGOS/lcFOS (9:1).

  • Improves allergic symptoms in infants with IgE-mediated atopic dermatitis [ 1 van der Aa, L.B., et al., Effect of a new synbiotic mixture on atopic dermatitis in infants: a randomized-controlled trial. Clin Exp Allergy, 2010. 40(5): p. 795-804. ]
  • Improves diaper dermatitis and gastrointestinal symptoms [ 1 van der Aa, L.B., et al., Effect of a new synbiotic mixture on atopic dermatitis in infants: a randomized-controlled trial. Clin Exp Allergy, 2010. 40(5): p. 795-804. ]
  • Prevents asthma-like symptoms [ 2 van der Aa, L.B., et al., Synbiotics prevent asthma-like symptoms in infants with atopic dermatitis. Allergy, 2011. 66(2): p. 170-7 ]

FERMENTS scGOS/lcFOS (9:1) and fermented milk
Gastrointestinal-related issues e.g. colic, spitting-up, are common causes of infant discomfort [ 1 Iacono, G., et al., Gastrointestinal symptoms in infancy: a population-based prospective study. Dig Liver Dis, 2005. 37(6): p. 432-8 ]. It has been shown that our prebiotic mixture scGOS/lcFOS (9:1) supports the functions of the immature digestive system in infants, i.e. nutrient digestion and absorption, softening of stools and improving gut comfort and well-being in infants [ 2, Costalos C, Kapiki A, Apostolou M, Papathoma E. The effect of a prebiotic supplemented formula on growth and stool microbiology of term infants. Early Hum Dev 2008; 84(1): 45-49 3, Moro G, Minoli I, Mosca M, Fanaro S, Jelinek J, Stahl B, Boehm G. Dosage related bifidogenic effects of galacto- and fructooligosaccharides in formula-fed term infants. J Pediatr Gastroenterol Nutr 2002; 34(3): 291-295 4 Boehm G, Lidestri L, Casetta P, Jelinek J, Jelinek J. Supplementation of a bovine milk formula with an oligosaccharide mixture increases counts of faecal bifidobacteria in preterm infants. Arch Dis Child Fetal Neonetal Ed 2002: F178-21 181 ].

Please click this link to find information about functional gastrointestinal disorders (FGIDs) in infancy and early life nutrition.

Based on the knowledge that the immune system keeps on developing at least until 3 years of age, Nutricia Research has combined expertise in immunity and gut health to support the immune system in toddlers. The combination of specific prebiotic mixture scGOS/lcFOS (9:1) and high n-3 LC-PUFA is clinically proven to support the immune system by positively influencing the intestinal microbiota and lcPUFA status in young children, resulting in reduced risk of infections
[ 1, Chatchatee, P., et al., Effects of growing-up milk supplemented with prebiotics and LCPUFAs on infections in young children. J Pediatr Gastroenterol Nutr, 2014. 58(4): p. 428-37 2 Rezaiki L., et al., A specific mixture of scGOS/lcFOS/LCPUFA increases faecal bifidobacteria in healthy young children. ].